Figure 1

Visualization of DEGs in PWH cohort. (a) Volcano plot showing DEGs with thresholds of absolute fold change > 1.5 and a BH adjusted p value < 0.5 in yellow. (b) Heatmap of relative expression levels of DEGs identified between infected and non-infected PWH. Values were scaled by row. (c) Boxplot of individual gene expression levels as normalized log₂ expression values for top four up-regulated DEGs. (d) Boxplot of individual gene expression levels as normalized log₂ expression values for top four down-regulated DEGs. healthy: healthy controls; HIV: non-infected PWH; HIV_RV: PWH infected with respiratory virus. Gene name abbreviations: Free Fatty Acid Receptor 3 (FFAR3), Neurotensin Receptor 1 (NTSR1), Maestro Heat Like Repeat Family Member 5 (MROH5), Cyclin A1 (CCNA1), Adenosine Deaminase RNA Specific B2 (ADARB2), Gamma-Glutamyltransferase 5 (GGT5), Peripheral Myelin Protein 22 (PMP22), Vitelline Membrane Outer Layer 1 Homolog (VMO1).