Figure 6
In silico prediction of CFAV, MODV, TBEV, NHUV, WNV and GUAPV 3′UTR and conserved secondary structure. Secondary structures were generated in Mfold software using 3′UTR sequences of each representative strain and structural elements were identified based on previous studies (see “Methods”). SL, stem-loop structure; DB, dumbbell structure; 3′SL, 3′ end stem-loop structure (also named as Flavi_CRE). In silico predicted MBFV xrRNAs-like structures are referred as SL-II and SL-IV, identified by Covariance Models. The structures were visualized in RNAplot software.
