Figure 2 | Scientific Reports

Figure 2

From: rs1944919 on chromosome 11q23.1 and its effector genes COLCA1/COLCA2 confer susceptibility to primary biliary cholangitis

Figure 2

rs1944919 genotypes are associated with differences in endogenous COLCA1, COLCA2, and POU2AF1 expression levels. (A–C) Effect of the rs1944919 genotype on endogenous expression of COLCA1 (A), COLCA2 (B), and POU2AF1 (C) in the esophageal mucosa. (D–F) e-QTL mapping of COLCA1 (D), COLCA2 (E), and POU2AF1 (F) in the esophageal mucosa. rs1944919, shown as red solid dots, exhibited the strongest association with COLCA1 and COLCA2 expression. Red open dots indicate rs4938534 which was the most significant SNP with PBC susceptibility on chromosome 11q23.1.

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