Figure 7
QUIMBI visualization (a) of human PXE skin showing a distinct distribution which is based on weak signals. (b) shows the corresponding histology and (c)–(f) selected single mass channel images. In this example visualization, the selected reference pixel in (a) comprises ten mass channels with a non-zero signal which are scaled to the same signal intensity due to the 8-bit scaling (g). The marked regions (dashed white lines) show a molecular distribution which is visible in the QUIMBI visualization (a) but not in the single mass channel images (c) to (f). All single mass channel images can be found in Supplementary G. The image intensity scale in (a) shows the similarity of pixels from black (dissimilar) to white (similar).
