Figure 8
QUIMBI visualization of human PXE skin showing a calcification layer (a), with corresponding histology (b), mean image of all mass channels (c) and single mass channel images (e)–(m). The image intensity scale in (a) shows the similarity of pixels from black (dissimilar) to white (similar). The QUIMBI visualization in (a) shows a distribution of weak signals for the selected reference pixel (white circle in a). The dashed line in the QUIMBI visualization (a) marks a calcification layer in the skin that is characteristic for PXE. In (d) the mass spectrum belonging to the reference pixel selected in (a) can be seen, which shows nine mass channels with non-zero signal. In (e)–(m) the single mass channel images are shown. The mean image of the nine mass channels is shown in (c). In all images, the region shown in (a) is marked with a dashed line. Only the QUIMBI visualization fully reveals the calcification layer.
