Figure 9

Comparison of QUIMBI visualization with and without matrix subtraction. The column on the left (a), (d), (g) shows the QUIMBI visualization of three different reference pixels (marked with arrows) in the human PXE skin data set, which was fully processed with ProViM. The matrix signal was subtracted and the picking threshold was set to 0.019, resulting in 329 mass channels. The columns in the middle (b), (e), (h) and on the right (c), (f), (i) show the QUIMBI visualizations at the same pixel position of the same data set but without matrix subtraction. The image intensity scales in all images show the similarity of pixels from black (dissimilar) to white (similar). In the middle, mass channels with the same threshold value of 0.019 were picked, resulting in 116 mass channels. For the right column no picking was performed, resulting in 17,384 mass channels in the QUIMBI visualization. The best color contrast between the similar and dissimilar pixels in the QUIMBI visualization is achieved when a matrix subtraction was performed.