Figure 6

P110 treatment prevents desflurane-induced perturbation of mitochondrial morphology. Fluorescent cropped images showing representative neurons from each condition (a–d). Quantification of predominant mitochondrial morphology in each treatment (e). Desflurane alone caused increased fragmentation. P110 alone did not affect mitochondrial morphologies. P110 pre-treatment, followed by desflurane exposure prevented anesthetic-induced aberrations. Two-Way ANOVA. ** p < 0.001 as determined by Tukey's multiple comparisons post-hoc test. Bars indicate ± SD across biological replicates. Each data-point indicates the percentage of cells that exhibited a specific morphology per biological replicate. Scale bars indicate 10 μm.