Table 3 Gene information from iPathwayGuide meta-analysis.
Gene symbol | Name | Methylation Log Fold Change; P-value | Gene expression Log Fold Change; P-value | Functional information | |
|---|---|---|---|---|---|
Unique to CP Cases | CSRP1 | Cysteine and Glycine Rich Protein 1 | − 0.209; p = 1.000e−6 | + 0.270; p = 0.015 | Gene regulation, cell growth and somatic differentiation; promotes skeletal muscle growth |
USP44 | Ubiquitin Specific Peptidase 44 | + 0.015; p = 1.000e–6 | + 0.261; p = 0.036 | Deubiquitinating enzyme; regulates spindle assembly checkpoint by preventing anaphase onset; regulates cell cycle progression and genomic stability | |
Unique to Controls | CRELB2 | cAMP responsive element binding protein like 2 | − 0.003; P = 2.460e−4 | − 0.302; P = 0.010 | Protein with DNA binding capabilities; may act as tumor suppressor gene |
DCAF11 | DDB1 and CUL4 associated factor 11 | + 0.006; P = 2.900e−5 | − 0.469; P = 9.326e−4 | Mediates degradation of stem-loop binding protein, regulates cell cycle/ viability | |
FEM1A | Fem-1 homolog A | + 0.007; P = 2.170e−4 | − 0.504; P = 2.404e−4 | Mediates degradation of stem-loop binding protein, regulates cell cycle/ viability | |
JAK1 | Janus kinase 1 | − 6.115e−4; P = 1.370e−4 | + 0.235; P = 0.044 | Protein-tyrosine kinase; key role in interferon-alpha, beta and gamma signal transduction |
