Table 2 The Top 5 candidate human HLA class II T cell potentially cross-reactive epitope pairs between SARS-CoV-2 and aero-and food-allergens based on pair combined score and application of additional clinical and conservation related criteria (see Fig. 1) (pipeline 1) Pcs = pair combined score.
MHC II | Top 30 pair combined score | ||||||
|---|---|---|---|---|---|---|---|
Candidate | Allergen epitope | Protein family | Viral epitope | MHC allele | pcs | ||
AERO | Nr.1 | Phl p 5 | FVATFGAAS | Group 5/6 grass pollen allergen | FSSTFNVPM | HLA-DRB1_04_01 | 87 |
Nr. 2 | Asp f 4 | LTALAAGSA | Unclassified | VTALRANSA | HLA-DRB1_01_01 | 479 | |
Nr. 3 | Phl p 5 | FVATFGAAS | Group 5/6 grass pollen allergen | FSSTFNVPM | HLA-DRB1_04_01 | 53 | |
Nr.4 | Phl p 5 | FVATFGPAS | Group 5/6 grass pollen allergen | FSSTFNVPM | HLA-DRB1_04_01 | 29 | |
Nr. 5 | Phl p 5 | FKVAATAAN | Group 5/6 grass pollen allergen | FSSTFNVPM | HLA-DRB1_04_01 | 38 | |
FOOD | Nr. 1 | Gal d 5 | FLYAPAILS | Serum albumin | FYILPSIIS | HLA-DRB1_01_01 | 299 |
Nr. 2 | Gal d 6 | ILVDAVLKE | Lipoprotein | VVADAVIKT | HLA-DRB1_03_01 | 113 | |
Nr. 3 | Gal d 6 | VYSDVPIEK | Lipoprotein | VVADAVIKT | HLA-DRB1_03_01 | 29 | |
Nr. 4 | Ara h 1 | FIMPAAHPV | Cupin | FVMMSAPPA | HLA-DRB1_01_01 | 258 | |
Nr. 5 | Gal d 5 | FLYAPAILS | Serum albumin | FLYENAFLP | HLA-DRB1_01_01 | 81 | |
