Figure 2 | Scientific Reports

Figure 2

From: Chromosomal translocation t(11;14) and p53 deletion induced by the CRISPR/Cas9 system in normal B cell-derived iPS cells

Figure 2

Knockout of p53 with the CRISPR/Cas9 system. (A) Induction of 83 bp deletion in exon 5 of p53 using the CRISPR/Cas9 system. (B) Confirmation of suppression of p53 expression in G#28 with western blotting. Induction of apoptosis by H2O2 enhanced TP53 expression in wt (BiPSC13), but TP53 expression was not observed in G#28 regardless of H2O2 treatment.

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