Figure 3
From: A novel missense mutation in the HSF4 gene of giant pandas with senile congenital cataracts
Effect of replacing a highly-conserved arginine residue with tryptophan between the isoform-specific and downstream hydrophobic regions of HSF4. Multiple alignment of a highly-conserved sequence of 25 amino acid residues in four orthologs of HSF4 (mouse, dog, human and panda) showing that the panda R377W substitution affects an arginine residue conserved across all species (equivalent to human residue R371).
