Figure 6
From: The SUN2-nesprin-2 LINC complex and KIF20A function in the Golgi dispersal
Working model for the regulation of the Golgi organization by LINC complex. Left, The minus-end-directed MT motor activity, i.e., dynein (blue), dominates plus-end-directed motor activity under a steady-state condition, and juxtanuclear accumulation of the Golgi complex is observed. Right, In SUN1-depleted cells, KIF20A is activated or suppression of KIF20A activity is cancelled, and KIF20A activity dominates dynein activity. An explanation for the inhibition of KIF20A activity in the presence of SUN1 is that LINC complex formations are biased towards SUN1 inclusion and SUN2/nesprin-2 LINC complex formation is suppressed. In response to SUN1 depletion, incorporation of nesprin-2 in the SUN1-LINC complex decreased and SUN2/nesprin-2 LINC complexes are formed. As a result, functions of KIF20A acting with a SUN2/nesprin-2 LINC complex becomes predominant (orange) over the minus-end-directed motor activities (blue), and the Golgi complex is dispersed.
