Figure 2

Results of the principal coordinate analysis (PCoA) showing differences in beta diversity between low-and high-fatigue patients. (a) PCoA plots using weighted-UniFrac metric. The x-axis explains 37.8% variation of the data. The y-axis explains 15.8% variation of the data. Each blue dot represents the PCoA score of one patient in the low-fatigue group; Each red triangle represents the PCoA score of one patient in the high-fatigue group. (b) PCoA plots using Bray–Curtis metric. The x-axis explains 9.4% variation of the data. The y-axis explains 6.7% variation of the data. The shaded ellipse denote the 80% confidence region of all the points. The dashed ellipse denote the 90% confidence region of all the points. (c) PCoA plot with individual distances to the centroid shows the inter-individual variations. Each blue dot represents the PCoA score of one patient in the low-fatigue group; Each red triangle represents the PCoA score of one patient in the high-fatigue group. (d) Boxplot of individual-centroid distances. The p-value is given by Tukey test. The box with blue color describes the distance distribution in the low fatigue group; The box with red color describes the distance distribution in the high fatigue group. (c,d) showed results from Bray–Curtis metric.