Table 1 Baseline and terminal characteristics of study groups.

From: Effect of captopril on post-infarction remodelling visualized by light sheet microscopy and echocardiography

 

Sham—vehicle

n = 10

LAD—vehicle

n = 12

LAD—captopril

n = 12

Body weight, onset of treatment (day 7) (g)

22.2 ± 0.3

22.6 ± 0.3

22.1 ± 0.2

Heart rate, day 7 (BMP)

488 ± 19

525 ± 12

515 ± 12

Daily water intake (g/day)

7.5 ± 0.2

7.2 ± 0.1

7.2 ± 0.1

Captopril dose (mg/kg/day)

-

-

640 ± 16

Body weight, termination (g)

22.6 ± 0.3

23.1 ± 0.3

22.4 ± 0.3 #

Heart weight, termination (mg)

134 ± 4

159 ± 6 **

138 ± 6 #

Heart weight ratio to tibia length, termination

7.7 ± 0.2

9.1 ± 0.4 *

7.8 ± 0.3 #

Heart rate, week 5 (BPM)

442 ± 18

484 ± 8

464 ± 16

LV chamber volume (mm)

38.5 ± 4.2

69.4 ± 4.7 ***

72.9 ± 5.1

  1. Body weight and echocardiography derived heart rate measured at the onset of treatment (day 7) and/or termination. Heart weight was measured after tissue clearing for light sheet imaging. End-diastolic LV chamber volume was estimated on parasternal long axis view at the time of termination. Data is mean ± s.e.m. One-way ANOVA with Tukey’s post hoc test. **p < 0.01 ***p < 0.001 vs sham—vehicle, #p < 0.05 vs LAD—vehicle.
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