Figure 6 | Scientific Reports

Figure 6

From: Ablation of kynurenine 3-monooxygenase rescues plasma inflammatory cytokine levels in the R6/2 mouse model of Huntington’s disease

Figure 6

Plasma cytokines TNFα, IL1β, IL4, IL5, IL6 were dysregulated in late stage R6/2 mice and levels rescued upon KMO ablation. Plasma cytokine levels were measured by Mesoscale Discovery technology for all six genotypes at 12 weeks of age. TNFα, IL1β, IL4, IL5, IL6 and IL10 levels were all altered in R6/2 as compared to WT. Both hetero- and homozygosity for Kmo resulted in rescue of these levels for all cytokines except IL10, and IL-5 was only rescued upon Kmo knockout. Statistical analyses via one-way ANOVA with Bonferroni post hoc correction. The test statistic, degrees of freedom and p values for the ANOVA are provided in Supplementary Table S12 online. WT:KMO+/+  = WT, WT:KMO+/−  = Kmo heterozygotes, WT:KMO−/−  = Kmo homozygotes, R6/2:KMO+/+  = R6/2, R6/2:KMO+/−  = R6/2 Kmo heterozygotes, R6/2:KMO−/−  = R6/2 Kmo homozygotes, WT = wild type.

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