Figure 4 | Scientific Reports

Figure 4

From: Higher PGD2 production by synovial mast cells from rheumatoid arthritis patients compared with osteoarthritis patients via miR-199a-3p/prostaglandin synthetase 2 axis

Figure 4

Effects of co-culture of OA patients’ synovial MCs with RA patients’ synovial fibroblasts on expression levels of mRNA for PTGS1, PTGS2, TBXAS1 and LTC4S in the OA patients’ MCs. (A) Comparison of expression levels of mRNA for PTGS1, PTGS2, TBXAS1 and LTC4S in fibroblasts obtained from OA (open bars, n = 4) and RA (closed bars, n = 4) patients. The data are shown as the ratio of the enzyme mRNA level to the β-actin mRNA level (× 10–4, mean ± SEM). (B) Effects of co-culture of OA patients’ synovium-derived, cultured MCs (n = 5) with RA patients’ fibroblasts (n = 2) on expression levels of mRNA for PTGS1, PTGS2, TBXAS1 and LTC4S in the OA patients’ MCs. The data are shown as the ratio of the enzyme mRNA level in the MCs alone to that in the MCs after co-culture with the RA patients’ fibroblasts (mean ± SEM).

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