Figure 5 | Scientific Reports

Figure 5

From: Combined nicotinamide N-methyltransferase inhibition and reduced-calorie diet normalizes body composition and enhances metabolic benefits in obese mice

Figure 5

IPA of the EWAT metabolome predicts inhibition of lipid synthesis as a major mechanistic pathway differentially modulated by NNMTi treatment relative to diet switch alone. IPA included all metabolites measured in the WD/LD-T group relative to the WD/LD-V group and predicted that lipid synthesis was inhibited with NNMTi treatment (p = 0.045, activation z-score = − 2.5660).

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