Figure 1 | Scientific Reports

Figure 1

From: Genetic dissection of down syndrome-associated alterations in APP/amyloid-β biology using mouse models

Figure 1

Mapping DS-AD associated phenotypes: analysis of progeny from crosses of J20 tgAPP with DS segmental duplication models. (A) Regions of Hsa21 homology on mouse chromosomes 16, 17 and 10 in the Dp(16)2Tyb, Dp(16)3Tyb, Dp(10)1Yey and Dp(17)1Yey segmental duplication models of DS. An ideogram of Hsa21 with major karyotypic bands is shown, with a megabase (Mb) scale. Below this are graphical representations of the relative sizes of Hsa21 orthologous regions in the mouse and the subregions which are segmentally duplicated in each DS mouse model used in this study. These are colour coded: Dp(16)2Tyb is light blue, Dp(16)3Tyb is green, Dp(10)1Yey is purple, and Dp(17)1Yey is yellow. “NA” refers to a subregion not modelled in this study. The number of Hsa21 orthologous genes, Mb size, first and last genes in each duplication are shown. (B) Schematic of the cross of the segmental duplication models of DS crossed with the J20 APP transgenic model (tgAPP).

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