Figure 2
The effect of DS segmental duplication models on J20 tgAPP-associated mortality. (A) Survival of Dp(16)2Tyb;tgAPP male and female mice to 6-months of age is significantly reduced compared to tgAPP controls (Mantel–Cox log-rank test Χ2 = 47.872 p < 0.001). (Wildtype male n = 21, female n = 16; Dp(16)2Tyb male n = 7, female n = 6; tgAPP male n = 16, female n = 12; Dp(16)2Tyb;tgAPP male n = 7, female n = 21). (B) Survival of Dp(16)3Tyb;tgAPP male and female mice to 6-months of age is significantly increased compared to tgAPP controls (Mantel–Cox log-rank test Χ2 = 33.58 p < 0.001). (Wildtype male n = 23, female n = 34; Dp(16)3Tyb male n = 19, female n = 20; tgAPP male n = 21, female n = 28; Dp(16)3Tyb;tgAPP male n = 18, female n = 20). (C) Survival of Dp(10)1Yey;tgAPP male and female mice to 6-months of age is significantly increased compared to tgAPP controls (Mantel–Cox log-rank test Χ2 = 8.414 p = 0.004). (Wildtype male n = 15, female n = 23; Dp(10)1Yey male n = 19, female n = 27; tgAPP male n = 17, female n = 18; Dp(10)1Yey;tgAPP male n = 11, female n = 22). (D) Survival of Dp(17)1Yey;tgAPP male and female mice to 6-months of age is significantly increased compared to tgAPP controls (Mantel–Cox log-rank test Χ2 = 12.56 p = 0.0057). (Wildtype male n = 14, female n = 18; Dp(10)1Yey male n = 11, female n = 15; tgAPP male n = 16, female n = 18; Dp(10)1Yey;tgAPP male n = 12, female n = 14). Both sexes included in analysis.
