Figure 3 | Scientific Reports

Figure 3

From: Age-dependent and region-specific alteration of parvalbumin neurons, perineuronal nets and microglia in the mouse prefrontal cortex and hippocampus following obesogenic diet consumption

Figure 3

Age and HFHS diet effects on hippocampal subregions. Mice that consumed HFHS diet had fewer (A,B) PV+ neurons in CA1, but not CA2/3 or DG. Adult mice that consumed HFHS diet had fewer PNNs in the CA1, however no group differences were seen in the CA3 or DG (C,D). There were significantly more PV/PNN colocalised neurons in the adult cohort (E,F) in the CA1 and CA2/3, but not DG. Data were assessed using two-way ANOVAs *p < 0.05, **p < 0.01. Representative photomicrographs were taken at 40X magnification (red—parvalbumin, green—WFA + PNN), scale bars show 100 μm.

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