Table 3 Mean and median concentrations of each marker for the three examined groups.

From: Validation and verification of predictive salivary biomarkers for oral health

Biomarkers or combinations thereof

Unit

Health (H) (N = 36)

Gingivitis (G) (N = 31)

Periodontitis (P) (N = 60)

(H) vs (G)

(H) vs (P)

(G) vs (P)

Ratios between different groups

Mean

Median

SD

Mean

Median

SD

Mean

Median

SD

p values

Ratio G/H

Ratio P/H

Ratio P/G

MMP-8

ng/ml

76.5

65.8

53.7

272.4

150.5

403.2

740.7

439.8

783.0

0.0012

< 0.0001

0.0002

3.56

9.69

2.72

MMP-9

ng/ml

57.0

46.2

42.2

162.8

117.0

141.5

423.4

353.8

327.1

0.0001

< 0.0001

< 0.0001

2.86

7.43

2.60

TIMP-1

ng/ml

209.3

192.7

80.0

180.6

151.4

124.2

101.5

74.3

90.8

0.0089

< 0.0001

0.0001

0.86

0.49

0.56

Ratio: MMP-8 / TIMP-1

no units#

0.49

0.34

0.85

1.68

1.11

2.01

16.51

5.01

50.21

0.0001

< 0.0001

< 0.0001

3.42

33.69

9.85

Ratio: MMP-9 / TIMP-1

no units#

0.320

0.225

0.283

1.305

0.723

1.973

8.916

4.001

16.029

< 0.0001

< 0.0001

< 0.0001

4.08

27.90

6.83

Sum: MMP-8 + MMP-9

ng/ml

133.5

106.0

87.8

435.2

258.3

489.0

1164.0

802.2

1056.9

0.0003

< 0.0001

< 0.0001

3.26

8.72

2.67

Ratio: (MMP-8 + MMP-9) / TIMP-1

no units#

0.81

0.53

1.07

2.98

1.77

3.82

25.43

10.02

64.04

< 0.0001

< 0.0001

< 0.0001

3.68

31.39

8.53

LBP

ng/ml

16.258

13.823

11.410

39.387

27.347

36.791

79.590

56.091

79.329

0.0004

< 0.0001

0.0058

2.42

4.90

2.02

MMP-2

ng/ml

0.883

0.670

0.790

2.033

1.800

1.550

6.503

4.565

6.849

0.0006

< 0.0001

< 0.0001

2.30

7.37

3.20

MMP-3

ng/ml

0.294

0.080

0.398

1.461

0.860

1.961

1.558

1.025

1.646

< 0.0001

< 0.0001

0.5577

4.97

5.30

1.07

OPG

pmol/l

1.196

1.045

1.071

1.759

1.160

2.733

4.539

3.585

3.677

0.6020

< 0.0001

< 0.0001

1.47

3.80

2.58

IL-1b

pg/ml

344

262

354

529

432

357

1147

1112

634

0.0036

< 0.0001

< 0.0001

1.54

3.34

2.17

IL-8

pg/ml

939

791

639

793

664

532

1094

939

764

0.5295

0.2259

0.0348

0.85

1.17

1.38

HGF

ng/ml

0.363

0.265

0.467

0.812

0.500

0.671

2.922

2.438

2.211

0.0004

< 0.0001

< 0.0001

2.24

8.05

3.60

  1. #The “ratio” and “combination” values were calculated per sample individually. As it is a ratio, there are no relevant units.
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