Figure 2
From: Apelin promotes blood and lymph vessel formation and the growth of melanoma lung metastasis
The effect of apelin overexpression and inhibition on the growth of experimental lung metastases. (A–C) Histological demonstration of lung metastases formed in the B16 Mock saline (A), B16 Ap saline (B) and B16 Ap MM54 (C) groups. Asterisks show the colony of the B16 Mock (A) or B16 Ap (B,C) melanoma cells in the lung. (D,E) Apelin overexpression significantly enhanced the number (D) and area (E) of B16 Ap lung metastases compared to the metastases of B16 Mock cells. Furthermore, the APJ antagonist MM54 had no impact on the number of metastases (D), but it significantly decreased the area of lung metastases formed by B16 Ap cells (E). *p < 0.05.
