Figure 3
From: Apelin promotes blood and lymph vessel formation and the growth of melanoma lung metastasis
Apelin has (lymph)angiogenic effect in mouse pulmonary metastases, which can be attenuated by MM54. Paraffin-embedded sections of lung metastases of apelin-overexpressing B16 Ap and B16 Mock cells were stained for the blood endothelial cell marker CD31 (A–C) and the lymphatic endothelial cell marker LYVE-1 (D–F). (G,H) Apelin overexpression significantly increased both the blood vessel (G) and lymph vessel (H) densities. This effect was attenuated by APJ receptor antagonist MM54 (G,H). *p < 0.05.
