Figure 2
From: Enteric reabsorption processes and their impact on drug pharmacokinetics
Pharmacokinetic model implemented in the analysis of (a) enterohepatic reabsorption (EHR), and (b) enterogastric reabsorption (EGR). Compartments: central compartment (C), gut (G), hepatocytes (H), gallbladder (B), stomach lumen (SL) and gastric parietal cells (S). First-order rate constants describing mass transferences: \({k}_{a}\) (drug absorption from the gut into the central compartment),\({k}_{gh}\)(hepatic uptake of drug coming from the gut through portal venous blood), \({k}_{g}\) (intestinal elimination), \({k}_{cg}\)(drug transference from the systemic circulation to the gut), \({k}_{hc}\) (drug transference from the hepatocyte to the central compartment), \({k}_{ch}\) (drug transference from the central compartment to the hepatocyte),\({k}_{h}\) (hepatic elimination), \({k}_{hb}\) (hepatobiliary secretion), \({k}_{cs}\) (drug transference from the central compartment to the parietal cells), \({k}_{sc}\) (drug transference from the parietal cells to the central compartment), \({k}_{s}\) (drug secretion from parietal cells into gastric lumen) \({k}_{sh}\) (hepatic uptake of drug coming from the parietal cells through the gastric vein), and \({k}_{r}\) (renal elimination).
