Figure 4
From: Enteric reabsorption processes and their impact on drug pharmacokinetics
Pharmacokinetic profiles simulated for an intravenous administration of 100 mg, drug A, in the EGR model. Drug amounts in the central compartment (\({A}_{C}\)), stomach tissue (\({A}_{S}\)), liver (\({A}_{H}\)), gut lumen (\({A}_{G}\)) and stomach lumen (\({A}_{SL}\)) are plotted versus time after dose. The multiple-peaking nature of the profiles corresponds to discrete gastric emptying events taking place every 8 h after with meal intake and followed by drug reabsorption into the central compartment.
