Table 2 Fractional method for arriving to an equation for oral drug bioavailability under enterohepatic reabsorption (EHR model).

From: Enteric reabsorption processes and their impact on drug pharmacokinetics

  1. \(D\): oral dose; \({E}_{gh}\): hepatocyte extraction ratio; \({F}_{a}:\) fraction of drug that reaches the systemic circulation from the gut; \({E}_{hb}:\) fraction of intra-hepatocytic drug that is submitted to hepatobiliary secretion; \({E}_{hc}: \text{fraction of intra-hepatocytic drug that reaches the systemic circulation.}\) See Table 1 for a mathematical description of these fractions.
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