Figure 2
From: Cycling hypoxia selects for constitutive HIF stabilization
Comparison environments with fixed intervals of short (10 min) and long (120 min) periods of cycling hypoxia. (A) Heatmap of the selection coefficients for the facultative strategy for all umin and umax combinations. Each star denotes the umin and umax combination that maximizes payoffs for the facultative strategy for each fixed interval time. (B) HIF-α (u) levels over time using the optimal facultative strategy. The unshaded areas represent periods of full oxygenation while the shaded grey areas represent periods of hypoxia. (C) Payoffs for separate strategies of HIF-α expression normalized to the perfect strategy. Parameters are given in Table 1.
