Figure 3
From: Cycling hypoxia selects for constitutive HIF stabilization
HIF-α regulation under stochastic fluctuations in oxygenation. (A) Optimal facultative HIF-α expression in stochastically hypoxic environment; r = 0.00048, α0 = 0.01155, α1 = 0.0462, m = 0.00083, b = 4, c = 0.0001328, and k = 1. Left graph illustrates HIF-α stabilization when the probability of fluctuations in oxygenation states is high (P = 0.1) and low (P = 0.0083). (B) Selection for a facultative strategy over a constitutive strategy for fixed interval and stochastic environments. Because selection is optimized numerically in fixed interval environments, the selection gradient is continuous. Selection in stochastic environments is presented as the average of 10 simulation results.
