Figure 7
From: Cycling hypoxia selects for constitutive HIF stabilization
Comparison of 3 HIF-α response strategies to changes in oxygen supply within the tumor (cell) microenvironment. The perfect strategy is instantaneous and used as an upper bound for comparison. Constitutive is constant over time, and facultative has a rate-limited response. The unshaded areas represent periods of full oxygenation while the shaded grey areas represent periods of hypoxia.
