Table 4 Multiple logistic regression analysis of symptoms in 40 patients with Whipple’s disease versus patients with palindromic arthritis, rheumatoid arthritis, psoriatic arthritis, and axial spondyloarthritis.

From: Differential diagnostic value of rheumatic symptoms in patients with Whipple’s disease

 

Odds ratio [odds ratio after backward selection]

95% CI [95% CI after backward selection]

Whipple’s disease versus the four rheumatic disorders tested

Male

3.408 [3.910]

1.299–8.942 [1.552–9.854]

Pain once per week

3.269 [3.434]

1.149–9.297 [1.284–9.183]

Episodic pain

2.584 [3.488]

0.836–7.990 [1.212–10.039]

 Pain affecting same joints

0.690

0.091–5.216

 Toes

0.390

0.136–1.116

 Saltatory pain

1.051

0.143–7.705

 Ankle pain

1.805

0.693–4.703

Whipple’s disease versus palindromic arthritis

Pain with rapid onset

0.175 [0.167]

0.043–0.708 [0.042–0.654]

Pain affecting same joints

559,853,342.0a [1155605404.0a]

0.000 [0.000]

 Shoulder

0.357

0.075–1.700

Whipple’s disease versus rheumatoid arthritis

Male

11.982 [14.285]

1.738–82.620 [2.166–94.215]

 Pain once per week

1.216

0.150–9.852

Episodic pain

9.806 [9.184]

1.203–79.951 [1.625–51.919]

 Rapid onset of pain

0.682

0.133–3.499

 Pain affecting same joints

0.750

0.048–11.714

Toes

0.052 [0.058]

0.007–0.396 [0.008–0.397]

Whipple’s disease versus psoriatic arthritis

Pain once per week

2.431

0.452–13.064

Episodic pain

4.831 [7.298]

1.045–22.342 [1.938–27.487]

Pain affecting same joints

0.953

0.047–19.142

Toes

0.149 [0.138]

0.024–0.923 [0.024 – 0.805]

Saltatory pain

1.081

0.052–19.919

Shoulder

8.170 [10.639]

1.002–66.643 [1.517–74.597]

Whipple’s disease versus axial spondyloarthitis

Pain once per week

1.554

0.194–12.493

Episodic pain

10.689 [15.035]

1.056–108.151 [1.711–132.100]

Affecting same joints

0.862

0.101–7.346

Saltatory pain

2.928

0.348–24.633

Sacral and ileosacral pain

0.013 [0.016]

0.001–0.158 [0.001–0.171]

Ankle pain

24.122 [26.757]

1.910–304.680 [2.436–293.874]

  1. Values greater than 1.0 suggest a constellation of symptoms favoring Whipple’s disease, lower values are indicative for one of the other disorders.
  2. aThere was no patient in the palindromatic group in whom the same joints were affected in the following attacks.