Table 3 Therapies after onset of the first acute exacerbation in patients with and without subsequent recurrence of acute exacerbation.

Therapy	Patients with recurrence of AE n = 9	Patients without recurrence of AE n = 54	p Value
Total dose of corticosteroid over
1 to 30 days
mg/month	3133 ± 1990	5185 ± 2414	0.02
mg/kg/month	57.2 ± 37.7	93.5 ± 44.0	0.03
31 to 60 days
mg/month	833 ± 238	809 ± 390	0.85
mg/kg/month	14.1 ± 5.2	13.9 ± 6.1	0.92
61 to 90 days
mg/month	700 ± 212	597 ± 218^a	0.19
mg/kg/month	11.8 ± 4.1	10.2 ± 3.5^a	0.25
91 to 120 days
mg/month	562 ± 212^b	526 ± 195^a	0.62
mg/kg/month	9.4 ± 3.6^b	9.1 ± 3.5^a	0.82
151 to 180 days
mg/month	387 ± 186^c	423 ± 162^d	0.61
mg/kg/month	6.2 ± 2.9^c	7.3 ± 3.1^d	0.39
Immunosuppressive agent, n (%)	1 (11.1%)	19 (35.1%)	0.25
Antifibrotic agent
Within 1 year after AE, n (%)	2 (22.2%)	6 (11.1%)	0.31
Additional therapy on admission
NIV	0 (0%)	6 (11.1%)	0.58
Antibiotics	7 (77.7%)	39 (72.2%)	> 0.99
PCP prophylaxis	9 (100%)	52 (96.2%)	> 0.99

Values are shown as actual numbers or means ± standard deviation.
^an = 50, ^bn = 8, ^cn = 6, ^dn = 48.
AE acute exacerbation, NIV noninvasive ventilation, PCP pneumocystis pneumonia.

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