Figure 4 | Scientific Reports

Figure 4

From: Interleukin-33 and thymic stromal lymphopoietin, but not interleukin-25, are crucial for development of airway eosinophilia induced by chitin

Figure 4

Importance of IL-5 for large-size chitin-induced airway eosinophilia. C57BL/6J-wild-type (n = 18–28), Il4−/− (n = 27), Il5−/− (n = 15) and Il13−/− (n = 13) mice were intranasally treated one time with 100 μg of chitin (large size: 70–100 μm) suspended in saline or with saline alone. Twenty-four hours later, BAL fluids were collected. (a) The eosinophils and neutrophils in the BAL fluids were counted. (b) The levels of IL-4, IL-5 and IL-13 in the BAL fluids were measured by ELISA. Data from 2 independent experiments were pooled and shown as the mean + SE *P < 0.05 vs. wild-type mice.

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