Figure 2 | Scientific Reports

Figure 2

From: Elevation of plasma tRNA fragments as a promising biomarker for liver fibrosis in nonalcoholic fatty liver disease

Figure 2

tRNA fragments are elevated in plasma from patients with NAFLD. Blood samples from 114 patients with NAFLD and 42 controls were analysed. (A,C,E) Cleavage sites are indicated (red triangle) on the mature tRNA structures (downloaded from GtRNAdb 2.0). (B,D,F) Predicted secondary structures of the tRNA fragments. (G) tRF-Val-CAC-005, (H) tiRNA-His-GTG-001, and (I) tRF-Ala-CGC-006 were significantly elevated in the NAFLD samples. Student’s t-test indicated p = 0.0045, p = 0.0027, and p = 0.0096, respectively. **p < 0.01. Data represent the mean ± SEM. ROC curve analysis indicated that (J) tRF-Val-CAC-005 had an AUC of 0.875 (p < 0.001), (K) tiRNA-His-GTG-001 had an AUC of 0.868 (p < 0.001), and (L) tRF-Ala-CGC-006 had an AUC of 0.840 (p < 0.001).

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