Table 1 Mean DCrt results obtained for the 51 genes that could be quantitatively determined, both during lactation and after weaning for CTR and ENR piglets. Details for the different genes can be found in Supplementary Table S4. (BF: Barrier function related genes/EH: Enzymes/Hormones related genes/IR: Immune system related genes/NT: Nutrient Transport related genes/ST: Stress related gene).

From: Early socialization and environmental enrichment of lactating piglets affects the caecal microbiota and metabolomic response after weaning

Function

Gene

LACT

WEAN

CTR

ENR

SEM

P-value

CTR

ENR

SEM

P-value

BF

TFF3

3.69

3.74

0.151

0.9254

3.17

3.21

0.197

0.9799

BF

OCLN

7.89

7.67

0.125

0.7494

6.97

7.13

0.075

0.8255

BF

ZO1

4.28

4.11

0.132

0.8836

4.06

3.83

0.090

0.7439

BF

CLDN1

17.51

16.07

0.550

0.7494

16.48

15.56

0.397

0.7466

BF

CLDN4

15.63

15.28

0.188

0.7494

14.64

14.83

0.204

0.8644

BF

CLDN15

9.00

8.58

0.234

0.7494

9.49

9.36

0.112

0.8255

BF

MUC2

5.37

5.61

0.211

0.8836

4.87

4.64

0.199

0.8255

BF

MUC13

2.43

2.30

0.294

0.9194

1.22

1.07

0.092

0.8255

EH

SI

3.07

2.74

0.323

0.8836

1.40

1.54

0.199

0.9888

EH

DAO1

2.95

2.74

0.373

0.9491

2.37

2.54

0.138

0.8255

EH

HNMT

5.49

5.16

0.157

0.9062

4.63

4.64

0.099

0.9799

EH

ANPEP

1.43

0.48

0.378

0.7788

0.37

0.33

0.120

0.9799

EH

IDO1

9.19

8.65

0.443

0.9062

8.21

7.35

0.318

0.7439

EH

GCG

4.95

4.17

0.220

0.6220

4.19

4.01

0.122

0.8255

EH

CCK

7.36

7.36

0.165

0.9925

9.15

9.77

0.303

0.8255

EH

IGF1R

6.39

6.15

0.171

0.8836

7.93

7.11

0.199

0.7439

EH

PYY

7.16

6.61

0.233

0.7494

6.83

7.04

0.194

0.8255

EH

GPX2

4.88

5.21

0.327

0.8836

5.65

4.45

0.395

0.7439

EH

SOD2.m

4.62

4.63

0.170

0.9925

5.00

4.49

0.133

0.7439

EH

ALPI

2.28

1.17

0.545

0.9194

0.54

1.23

0.196

0.7439

IR

TLR2

13.57

13.15

0.234

0.7494

13.94

11.69

0.391

0.0315

IR

TLR4

7.63

7.55

0.179

0.9254

8.07

7.22

0.291

0.7439

IR

IL1B

10.79

9.57

0.354

0.6220

9.61

9.00

0.342

0.8255

IR

IL6

13.62

12.70

0.373

0.7494

13.20

12.67

0.270

0.8255

IR

IL10

10.24

9.91

0.171

0.7494

9.55

9.58

0.173

0.9799

IR

IL17A

17.86

17.43

0.469

0.8836

16.58

16.67

0.470

0.9799

IR

IL22

12.57

12.10

0.583

0.8836

11.84

11.91

0.324

0.9799

IR

IFN-γ

9.86

9.05

0.448

0.7494

9.13

8.85

0.261

0.8255

IR

TNF-α

9.62

8.97

0.231

0.7494

9.08

8.56

0.186

0.7439

IR

TGF-β1

5.29

5.33

0.101

0.9254

5.22

5.01

0.148

0.8255

IR

CCL20

5.88

4.77

0.561

0.7494

4.64

4.79

0.392

0.9799

IR

CXCL2

10.23

9.10

0.373

0.7494

10.15

9.65

0.309

0.8255

IR

IFNGR1

4.78

4.58

0.214

0.8813

3.29

3.36

0.094

0.9115

IR

HSP27

3.35

2.83

0.228

0.7494

2.97

3.35

0.128

0.7439

IR

HSP70

3.51

3.24

0.186

0.8698

3.24

3.24

0.075

0.9964

IR

REG3G

6.38

6.58

0.502

0.9254

7.02

3.74

0.970

0.7439

IR

PPARGC1α

7.28

7.28

0.147

0.9925

7.90

8.09

0.159

0.8255

IR

FAXDC2

6.23

4.52

0.490

0.6825

4.05

4.76

0.298

0.7164

IR

GBP1

3.19

2.59

0.329

0.8797

2.77

2.63

0.131

0.8255

IR

IL8

4.67

4.39

0.245

0.8836

4.78

4.53

0.200

0.8255

NT

SLC5A1

2.38

1.97

0.530

0.9491

1.35

1.46

0.252

0.8225

NT

SLC16A1

6.44

6.78

0.196

0.9062

7.86

7.65

0.166

0.8255

NT

SLC7A8

8.03

5.84

0.621

0.6220

7.73

7.18

0.432

0.8255

NT

SLC15A1

5.18

4.00

0.463

0.7788

3.14

3.80

0.264

0.7907

NT

SLC13A1

7.55

5.07

0.576

0.6825

4.15

4.62

0.181

0.7798

NT

SLC11A2

6.63

6.58

0.092

0.9254

6.99

6.84

0.117

0.8255

NT

SLC30A1

5.07

4.48

0.171

0.7326

3.59

3.77

0.136

0.8255

NT

SLC39A4

4.54

4.70

0.202

0.8836

5.91

6.29

0.152

0.7439

ST

CRHR1

15.00

15.68

0.362

0.7494

15.20

15.14

0.333

0.9799

ST

NR3C1-Grα

6.59

6.11

0.123

0.7326

6.51

6.41

0.089

0.8255

ST

HSD11B1

8.56

8.98

0.184

0.8486

10.24

9.42

0.270

0.7439

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