Figure 2
Y maze cognitive function test in mice. B6 mice were injected in the tail vein 3 times per week for 3–6 consecutive weeks with nVLDL (15 μg/g), metVLDL (15 μg/g), or an equivalent volume of saline (control). The percentage (%) of time spent in the start arm A, familiar arm B, or novel arm C after 3 weeks (a–c) or 6 weeks (d–f) of injections is shown for the indicated group. The moving track of control (g), nVLDL (h), and metVLDL (i) mice is shown, determined by using video-tracking software (Panlab Smart video-tracking software, version 3.0). Data are presented as the mean ± standard error of the mean (n ≥ 12 in each group). *p < 0.05, ***p < 0.0001 arm C versus A, #p < 0.05, ###p < 0.0001 arm C versus B within each group. P-values were determined by using one-way analysis of variance with the Newman-Keuls post-hoc test.
