Table 1 Protein expression analysis in mouse plasma and brain after 6 weeks of tail-vein injections with nVLDL, metVLDL, or saline.

From: Electronegative very-low-density lipoprotein induces brain inflammation and cognitive dysfunction in mice

Variable

Saline (control)

nVLDL

metVLDL

F value

P value

n = 12

n = 12

n = 13

Plasma

Aβ42 (pg/mL)

80.0 ± 28.4

61.7 ± 26.3

202.5 ± 47.5

2.6

0.06

TNF-α (pg/mL)

0.5 ± 0.5

1.6 ± 1.0

4.0 ± 1.2*

3.9

0.05

Brain tissue

Cortex Aβ42 (pg/mg tissue)

55.5 ± 4.1

77.2 ± 7.1*

84.7 ± 7.2*

5.6

0.01

mPFC TNF-α (pg/mg protein)

10.4 ± 1.3

13.3 ± 1.5

17.9 ± 2.8*

3.6

0.04

Hip TNF-α (pg/mg protein)

7.6 ± 1.6

12.4 ± 2.8

30.8 ± 10.9

3.0

0.07

  1. Aβ42, amyloid beta 42; mPFC, medial prefrontal cortex; Hip, hippocampus; nVLDL, VLDL from healthy volunteers; metVLDL, VLDL from patients with metabolic syndrome. Data are presented as the mean ± standard error of the mean.
  2. *p < 0.05 versus control group. P-values were determined by using one-way analysis of variance with the Newman-Keuls post-hoc test.
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