Figure 7
From: Islet sympathetic innervation and islet neuropathology in patients with type 1 diabetes
Islet neuropathology pathways in AAb and T1D donors. (a) Nanostring neuropathology pathways with significantly different gene regulation between the donor groups are shown by colored line plots with pathways listed in the side-box (n = 4 no diabetes, n = 4 Autoab Pos (AAb), n = 4 T1D donors). (b) Bar and whisker plots (median, range) of relative gene expression levels for transmitter synthesis and storage, transmitter release, transmitter response and update, and vesicle trafficking that were significantly downregulated in T1D donors. Donor types are ordered as in (a) (c) Bar and whisker plots (median, range) of relative gene expression levels for activated microglia, cytokines, unfolded protein response (UPR) and oxidative stress pathways that were significantly upregulated in T1D donors. See Supplementary Tables S6–7 for additional details.
