Table 1 Sympathetic innervation of islets in T1D.
From: Islet sympathetic innervation and islet neuropathology in patients with type 1 diabetes
Islet sympathetic nerve changes | Species (model) | First author | Year | Journal | Major similarities | Major differences | References |
|---|---|---|---|---|---|---|---|
Fewer contacts | Rat (STZ, Biobreeder) | Tominaga, M | 1987 | Diabetes | Electron microscopy (EM): Intact sympathetic nerve endings | EM: Fewer α-cell contacts | |
Loss | Rat (Biobreeder) | Mei, Q | 2002 | Diabetes | Cryosections (16 µm) | Primary antibody: VMAT2 | |
Loss | Mouse (NOD) | Persson-Sjögren, S | 2005 | J Neuroimmunol | Cryosections (8 µm) | Primary antibody: UCHL1; islet acetylcholinesterase activity | |
Loss | Mouse (NOD) | Taborsky, G.J | 2009 | Diabetologia | Cryosections (16 µm) | Primary antibody: NPY | |
Loss | Human | Mundinger, T.O | 2016 | Diabetes | Primary antibody (TH, Millipore) | Autopsy specimens; Samples: 4 µm formalin-fixed paraffin | |
Loss | Canine (spontaneous diabetes) | Gilor, C | 2020 | Scientific Reports | Necropsy samples; Primary antibody: Rat anti-TH (PelFreeze Biologicals); Samples: 4 µm formalin-fixed paraffin | ||
Increased, remodeling | Mouse (STZ, NOD) | Chiu, Y.-C | 2012 | Diabetologia | Primary antibody (TH, Millipore); Optical clearing 400 µm sections | ||
Increased | Mouse (NOD) | Alvarsson, A | 2020 | Science Advances | Primary antibody (TH, Millipore); Optical clearing mm thick sections |
