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Figure 3

From: Efficiency of nilotinib to target chronic phase-chronic myeloid leukaemia primary mature CD34− and immature CD34+ cells

Figure 3

Relationship between intracellular nilotinib concentration and TKI efficiency in vitro. (A) The relationship between intracellular nilotinib (ICNIL; after 2 h of incubation) and nilotinib efficiency (i.e. inhibition of CrkL phosphorylation, pCrkL, and cell survival at 30 h of incubation) was evaluated in mature CD15+CD34- (PNM) and (B) immature CD15-CD34+ cells (n = 3) after incubation with the indicated concentrations of nilotinib (extracellular nilotinib). Results are the mean ± standard deviation.

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