Table 1 List of genes controlled in coupled pathways by the selected two miRNAs.
From: Triple negative aggressive phenotype controlled by miR-135b and miR-365: new theranostics candidates
Pairwise pathway | miRNAs | Genes in pathway 1 | Genes in pathway 2 |
|---|---|---|---|
1. Ethanol degradation; | Hsa-miR-135b (predicted Up) | ACSL1/3, ALDH1A1/1B1/3A24A1 | FEN1, MSH6, RFC2, RFC4, RPA1, SLC19A1 |
2. Mismatch repair | |||
1. Role of BRCA1 in DNA Damage Response | Hsa-miR-365–2 (predicted Down) | ATR, CHEK2, E2F1, MLH1, FANCA/B/C/E, MSH6, NBN, PLK1, RB1, RBBP8, RBL1, RFC5 | ALDH1A1/1A3/2, IL4I1, MAOA, SMOX |
2. Putrescine Degradation III | |||
1. Tryptophan Degradation X | Hsa-miR-365–2 (predicted Down) | ALDH1A1/1A3/2, IL4I1, MAOA, SMOX | ATR, CHEK2, E2F1, FANCA, FANCB, FANCC, FANCE, MLH1, MSH6, NBN, PLK1, RB1, RBBP8, RBL1, RFC5 |
2. Role of BRCA1 in DNA Damage response |
