Figure 4
From: Anti-mucin 1 chimeric antigen receptor T cells for adoptive T cell therapy of cholangiocarcinoma
Phenotypes, activation and exhaustion markers, and memory subsets of anti-MUC1-CAR4 T cells analyzed by flow cytometry. The phenotypic analyses of unactivated PBMCs (green), PHA-activated lymphocyte (yellow), and anti-MUC1-CAR4 T cells (red) were summarized: (a) cellular phenotypes (n = 4, mean ± SD); (b) activation markers (CD25 and CD69) (n = 3, mean ± SD); (c) exhaustion markers (LAG-3, TIM-3, and PD-1) (n = 3, mean ± SD); and (d) memory subsets (n = 5, mean ± SEM). The statistical differences were analyzed by Student t-test (asterisks represent p-values: *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001).
