Figure 5
From: Anti-mucin 1 chimeric antigen receptor T cells for adoptive T cell therapy of cholangiocarcinoma
TNF-α and IFN-γ production by anti-MUC1-CAR4 T cells following exposure to CCA cells. The representative cell gating data of (a) TNF-α and (b) IFN-γ cytokine production in untransduced (UTD) T cells, UTD T cells plus target cells, anti-MUC1-CAR4 T cells alone, and anti-MUC1-CAR4 T cells co-cultured with MMNK-1, KKU100, and KKU-213A. The percentages of TNF-α (c) and IFN-γ (d) producing cells plotted as bar graphs were individually averaged from 3 independent experiments (mean ± SD). All data were analyzed by Student t-test (asterisks represent p-values: *p < 0.05, **p < 0.01, ***p < 0.001).
