Table 2 MPV: mean platelet volume.

From: Long-term treated HIV infection is associated with platelet mitochondrial dysfunction

Platelet indices

PLHIV (n = 208)

Healthy controls (n = 56)

p-value

Platelet count (109/L)

260 [200, 310]

270 [210, 320]

0.126

MPV (fL)

10.1 [9.7, 10.7]

10.8 [10.3, 11.3]

< 0.001

IPF (%)

3.3 [2.5, 4.6]

3.7 [2.8, 5.9]

0.018

Unstimulated fibrinogen binding (MFI)

2.0 [1.6, 2.2]

2.1 [1.6, 2.4]

0.072

Unstimulated P-selectin expression (MFI)

2.7 [2.1, 3.2]

2.6 [2.2, 3.0]

0.158

Plasma CCL5 (ng/ml)

2.66 [1.64, 4.29]

2.61 [1.69, 4.18]

0.841

Plasma CXCL4 (ng/mL)

570.0 [290.0, 723.3]

492.9 [306.1, 839.5]

0.201

Plasma CXCL7 (ng/mL)

289.4 [180.3, 465.1]

306.6 [194.2, 609.8]

0.192

sCD14 (ng/mL)

2139.6 [1778.2, 2661.5]

1789.0 [1502.7, 2071.6]

< 0.001

sCD163 (ng/mL)

716.5 [528.7, 899.4]

517.3 [410.7, 578.1]

< 0.01

hsCRP (ng/mL)

1423.3 [608.8, 2726.3]

651.2 [205.9, 1179.2]

< 0.001

  1. Unstimulated platelet aggregation measured as Fibrinogen binding by flowcytometry in median fluorescence intensity (MFI). Unstimulated platelet degranulation measured as P-selectin expression by flow cytometry by MFI.
  2. Data were analyzed using Mann–Whitney U test.
  3. IPF immature platelet fraction as a percentage of platelet count (Sysmex, Kobe, Japan); sCD14 serum levels of CD14, a marker of monocyte activation; sCD163 serum levels of CD163, a monocyte- and macrophage-specific scavenger receptor; hsCRP high sensitive C-reactive protein.
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