Table 2 Brain activity-dependent genes are enriched in the population of genes affected by the simulated PMI.

From: Selective time-dependent changes in activity and cell-specific gene expression in human postmortem brain

FC (FDR 1%)

Total

Regulation

PMI-stable

PMI-not-stable

|1.5|

524

Up or down

99

356 (E = 4.1)

|1.4|

863

Up or down

182

543 (E = 3.4)

|1.3|

1998

Up or down

580

1065 (E = 2.1)

   

Average enrichment

E = 3.2

  1. We tested three groups of genes using fold change (FC) cutoffs of 1.3, 1.4 and 1.5 (corresponding to the absolute values of the ratio of expression of high brain activity genes divided by the expression of low activity brain genes). The significance used was FDR ≤ 1%. A total of 6754 genes (43%) were detected as stable, 5947 (38%) were identified as not stable from 0 to 24H simulated PMI. We then calculated the enrichment in brain activity-dependent genes inside each group and labeled these as ‘PMI not-stable’. Enrichment was calculated as the ratio between the quantity of brain activity-dependent genes that were not stable as a function of simulated PMI divided by the quantity of brain activity-dependent genes that were stable.
  2. E Enrichment.
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