Table 4 Summary of the effects caused by serotype switching from serotype 2 on in vivo and in vitro virulence analyzed in this study.
Strain | Serotype | In vitro | In vivo | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Porcine NPTr cells | Murine macrophages | Murine DCs | Murine blood | Porcine blood | Mice | Pig (Exp. I) | Pig (Exp. II) | |||||||
Adhesion | Invasion | Anti-phagocytosis | Pro-inflammatory mediator production | Resistance to killing | Mortality | Blood burden | Pro-inflammatory mediator production | Morbidity | Organ dissemination | Morbidity | Organ dissemination | |||
SS2to3 | 3 | – | – | – | – | ↓ | ↓ | – | ↓ | ↓ | NT | NT | – | ↑ |
SS2to4 | 4 | – | – | – (↓)a | ↓ | ↓ | ↓ | ↓ | ↓ | ↓ | ↓ | ↓ | NT | NT |
SS2to7 | 7 | ↑ | – | – (↓)a | – | – | ↓ | – | – | – | ↓ | ↓ | NT | NT |
SS2to8 | 8 | ↑ | – | – (↓)a | ↑ | – | – | ↑ | ↑ | ↑ | NT | NT | ↑ | ↑ |
SS2to9 | 9 (variant) | – | – | – | – | – | ↓ | – | – | – | NT | NT | NT | NT |
SS2to14 | 14 | – | – | – | – | – | ↓ | – | – | – | NT | NT | – | ↑ |
ΔCPS2 | Non-typable | ↑ | ↑ | ↓ | ↑ | ↓ | ↓ | ↓ | ↓ | ↓ | ↓ | ↓ | NT | NT |
