Figure 2
Maintenance of blood pressure, as measured by total norepinephrine (NE) administered, and several plasma measures of inflammation and membrane damage are associated with elevated levels of microbial alpha diversity. (A) Number of distinct features, a metric of richness, against low or high total NE (µg) required for maintenance of an appropriate blood pressure following polytrauma (PT) + hemorrhagic shock (HS), or HS alone, (B) Faith’s phylogenetic diversity against low or high plasma monocyte chemoattractant protein-1 concentration (MCP-1, pg/ml), (C) Shannon’s diversity index against low or high plasma interleukin-6 concentration (IL-6, pg/ml), (D) Shannon’s diversity index against low or high plasma junctional adhesion molecule A concentration (JAM-A, pg/ml), (E) Shannon’s diversity index against low or high plasma creatinine concentration (pg/ml), (F–H) Pielou’s J’ against (F) low or high plasma IL-6 concentration (pg/ml), (G) low or high plasma JAM-A concentration (pg/ml), and (H) low or high plasma creatinine concentration (pg/ml). The bottoms and tops of boxes indicate the first and third quartiles, respectively; whiskers indicate the 1.5 interquartile range beyond the upper and lower quartiles. Values outside the whiskers are indicated by gray circles; numbers in each box indicate sample sizes. Statistical significance in each categorical variable was evaluated using Kruskal–Wallis ranks-sums tests with post hoc pairwise Mann–Whitney U tests at p < 0.05. *p < 0.05; HS hemorrhagic shock, IL-6 interleukin 6, IQR interquartile range, JAM-A junctional adhesion molecule A, MCP-1 monocyte chemoattractant protein-1, NE norepinephrine, PT polytrauma.
