Figure 5
Several features in a linear mixed-effects analysis of composition of microbiomes (ANCOM-II)-based analysis of the cecal microbiome were used to identify taxa driving differences in plasma creatinine responses to polytrauma (PT) and hemorrhagic shock (HS). ANCOM-II volcano plots showing W-statistic against center-log ratio (CLR)-fold change differences between (A) low and high plasma creatinine levels, with non-significant taxa under the coefficient of concordance threshold of 0.6 (dashed-line) and significant taxa above the threshold. Structural zeros are points identified by ANCOM-II in peach; non-structural zeros, or taxa with non-infinity W-statistic values, are in blue. Relative abundances of (B) Leptotrichia oral clone FP036, indicated as a significant, non-structural zero taxon (W-statistic: 99) in panel (A). The bottoms and tops of boxes indicate the first and third quartiles, respectively; whiskers indicate the 1.5 interquartile range beyond the upper and lower quartiles. Values outside the whiskers are indicated by black circles. ANCOM-II analysis of composition of microbiomes II, CLR center-log ratio, HS hemorrhagic shock, PT polytrauma.
