Table 5 Types of cancer in relatives and patients’ tumor characteristics.

	Breast/ovarian cancer only (n = 617)		Multiple types of cancer (n = 159)		No family history of cancer (n = 7734)		p 1*	p2*	p3*
	N	%	N	%	N	%	p 1*	p2*	p3*
Age at diagnosis (years)
Age range	23–88		27–79		18–89		0.316	0.697	0.164
Median age	52.2		53.4		52.3		0.316	0.697	0.164
Primary tumor stage
T0	48	7.8	13	8.2	550	7.1	0.868	0.536	0.606
T1	173	28.0	48	30.2	2097	27.1	0.592	0.619	0.388
T2	343	55.6	86	54.1	4463	57.7	0.734	0.306	0.361
T3	44	7.1	10	6.3	506	6.5	0.710	0.570	0.898
T4	9	1.5	2	1.3	118	1.5	1.000	0.896	1.000
Lymph node stage
N0	398	64.5	97	61.0	4667	60.3	0.413	0.042	0.866
N1	138	22.4	40	25.2	1823	23.6	0.455	0.497	0.641
N2	43	7.0	10	6.3	678	8.8	0.762	0.126	0.273
N3	38	6.2	12	7.5	566	7.3	0.525	0.285	0.913
TNM stage
0	48	7.8	13	8.2	546	7.1	0.868	0.503	0.587
I	123	19.9	35	22.0	1486	19.2	0.562	0.662	0.376
II	350	56.7	83	52.2	4201	54.3	0.306	0.248	0.596
III	94	15.2	28	17.6	1484	19.2	0.463	0.016	0.617
IV	2	0.3	0	0	17	0.2	1.000	0.647	1.000
Histologic grade
I	20	3.2	3	1.9	292	3.8	0.599	0.501	0.214
II	445	72.1	130	81.8	5858	75.7	0.013	0.044	0.079
III	152	24.6	26	16.4	1584	20.5	0.027	0.014	0.201
ER/PR status
Positive	443	71.8	123	77.4	5779	74.7	0.159	0.109	0.449
Negative	174	28.2	36	22.6		25.3	0.159	0.109	0.449
HER2 status
Positive	83	13.5	14	8.8	1102	14.2	0.114	0.585	0.051
Negative	534	86.5	145	91.2		85.8	0.114	0.585	0.051
Ki-67 status
High	405	65.6	100	62.9	4908	63.5	0.517	0.279	0.883
Low	212	34.4	59	37.1	2826	36.5	0.517	0.279	0.883
Subtypes
Luminal A	141	22.9	32	20.1	1763	22.8	0.461	0.974	0.427
Luminal B	302	48.9	91	57.2	4016	51.9	0.062	0.154	0.185
HER2	48	7.8	8	5.0	621	8.0	0.232	0.826	0.167
TNBC	126	20.4	28	17.6	1334	17.2	0.428	0.046	0.905

*p1: single-FH vs. multiple-FH. p2: single-FH vs. non-FH. p3: multiple-FH vs. non-FH.

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