Figure 5
False-negative RDT results occurred in the setting of high HRP2 antigenemia. A Luminex bead-based immunoassay for three parasite antigens confirmed circulating HRP2 antigen in the majority of RDT-negative but PCR-positive/microscopy-positive isolates tested (RDT-negative). RDT-positive controls selected from the same facility are included for comparison. One pLDH value with background-subtracted MFI < 0 is not depicted. Log-transformed plots are provided in Supplementary Fig. 3. HRP2 P. falciparum histidine-rich protein 2, pAldolase Plasmodium aldolase, pLDH Plasmodium lactate dehydrogenase.
