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Figure 2

From: Early escitalopram administration as a preemptive treatment strategy against spasticity after contusive spinal cord injury in rats

Figure 2

Effects of escitalopram on spastic behaviors during the swimming test and the ratio of spasticity-strong rats. (A) The configuration of the swimming test used in this study is presented. Spasm and clonus phases during the swimming test were counted in 10 swimming runs. WT water temperature. (B) The bar graph shows the mean occurrence frequency of spastic behavior (sum of spasm and clonus) during the swimming tests performed at 3 and 4 weeks after SCI (gray bar with round plots: vehicle-treated group, white bar with rectangular plots: escitalopram-treated group). *P < 0.05, **P < 0.01. (C) The ratios of spasticity-strong rats at 3 and 4 weeks after SCI. Injured rats were classified as “spasticity-strong” if they showed over 40% frequency of spasticity-positive swimming runs during the swimming test.

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